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Year Number of Results
1997 1
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Page 1
FHL2 inhibits the Id3-promoted proliferation and invasive growth of human MCF-7 breast cancer cells.
Chen YH, Wu ZQ, Zhao YL, Si YL, Guo MZ, Han WD. Chen YH, et al. Chin Med J (Engl). 2012 Jul;125(13):2329-33. Chin Med J (Engl). 2012. PMID: 22882857
This study aimed to investigate the effects of FHL2 on the transcriptional regulation and oncogenic activities of Id3 in human breast cancer cells. ...The functional roles of FHL2-Id3 signaling in the development of human breast cancer need further res …
This study aimed to investigate the effects of FHL2 on the transcriptional regulation and oncogenic activities of Id3 in human bre …
The FHL2 regulation in the transcriptional circuitry of human cancers.
Cao CY, Mok SW, Cheng VW, Tsui SK. Cao CY, et al. Gene. 2015 Nov 1;572(1):1-7. doi: 10.1016/j.gene.2015.07.043. Epub 2015 Jul 26. Gene. 2015. PMID: 26211626 Free PMC article. Review.
The expression of FHL2 is found in different tissues and organs and has been reported as a critical participant influencing the wide types of cancer such as breast cancer, gastrointestinal (GI) cancers, liver cancer and prostate cancer. ...In this review, we will fi …
The expression of FHL2 is found in different tissues and organs and has been reported as a critical participant influencing the wide …
FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells.
Martin BT, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, Strebhardt K. Martin BT, et al. Cell Cycle. 2007 Jul 15;6(14):1779-88. doi: 10.4161/cc.6.14.4448. Cell Cycle. 2007. PMID: 17682292
Here we analyzed for the first time the molecular function of FHL2 in breast cancer. FHL2 is overexpressed in almost all human mammary carcinoma samples tested but not in normal breast tissues and only low levels of FHL2 expression were present …
Here we analyzed for the first time the molecular function of FHL2 in breast cancer. FHL2 is overexpressed in almost al …
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.
Yan J, Zhu J, Zhong H, Lu Q, Huang C, Ye Q. Yan J, et al. FEBS Lett. 2003 Oct 9;553(1-2):183-9. doi: 10.1016/s0014-5793(03)00978-5. FEBS Lett. 2003. PMID: 14550570 Free article.
BRCA1 interacted with FHL2 through its second BRCT domain and the interaction of FHL2 with BRCA1 requires the last three LIM domains of FHL2. ...Reverse transcription polymerase chain reaction analysis showed that FHL2 mRNA levels may be downregulated …
BRCA1 interacted with FHL2 through its second BRCT domain and the interaction of FHL2 with BRCA1 requires the last three LIM d …
Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells.
Xiong Z, Ding L, Sun J, Cao J, Lin J, Lu Z, Liu Y, Huang C, Ye Q. Xiong Z, et al. IUBMB Life. 2010 Sep;62(9):669-76. doi: 10.1002/iub.367. IUBMB Life. 2010. PMID: 20734429 Free article.
However, little is known about the biological function of FHL2 in breast cancer. Here, we report that FHL2 physically and functionally interacts with estrogen receptors (ERalpha and ERbeta), important regulators of breast cancer development and progres …
However, little is known about the biological function of FHL2 in breast cancer. Here, we report that FHL2 physically a …
Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.
Durso DF, Bacalini MG, Sala C, Pirazzini C, Marasco E, Bonafé M, do Valle ÍF, Gentilini D, Castellani G, Faria AMC, Franceschi C, Garagnani P, Nardini C. Durso DF, et al. Oncotarget. 2017 Apr 4;8(14):23237-23245. doi: 10.18632/oncotarget.15573. Oncotarget. 2017. PMID: 28423572 Free PMC article.
We calculated DNA methylation age acceleration using five state-of-the-art estimators (three multi-site: Horvath, Hannum, Weidner; and two CpG specific: ELOV2 and FHL2) in a cohort including 845 subjects from the EPIC-Italy project and we compared 424 samples that remained …
We calculated DNA methylation age acceleration using five state-of-the-art estimators (three multi-site: Horvath, Hannum, Weidner; and two C …
Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.
Boateng LR, Bennin D, De Oliveira S, Huttenlocher A. Boateng LR, et al. J Biol Chem. 2016 Jul 1;291(27):13987-13998. doi: 10.1074/jbc.M116.725739. Epub 2016 Apr 26. J Biol Chem. 2016. PMID: 27129278 Free PMC article.
Here we report that depletion of mAbp1 or ectopic expression of the ADFH domain of mAbp1 increased Rho GTPase signaling and breast cancer cell invasion. Moreover, cell invasion induced by the ADFH domain of mAbp1 required the expression of FHL2. Taken together, our …
Here we report that depletion of mAbp1 or ectopic expression of the ADFH domain of mAbp1 increased Rho GTPase signaling and breast ca …
KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.
Yan Q, Zhang W, Wu Y, Wu M, Zhang M, Shi X, Zhao J, Nan Q, Chen Y, Wang L, Cheng T, Li J, Bai Y, Liu S, Wang J. Yan Q, et al. Oncotarget. 2015 Sep 22;6(28):25402-17. doi: 10.18632/oncotarget.4517. Oncotarget. 2015. PMID: 26320172 Free PMC article.
In vivo, KLF8 promoted FHL2-mediated proliferation and metastasis via orthotopic implantation. Taken together, this work identified KLF8-induced FHL2 activation as a novel and critical signaling mechanism underlying human breast/colorectal cancer invasion and …
In vivo, KLF8 promoted FHL2-mediated proliferation and metastasis via orthotopic implantation. Taken together, this work identified K …
Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells.
Putnik M, Zhao C, Gustafsson JÅ, Dahlman-Wright K. Putnik M, et al. Biochem Biophys Res Commun. 2012 Sep 14;426(1):26-32. doi: 10.1016/j.bbrc.2012.08.007. Epub 2012 Aug 10. Biochem Biophys Res Commun. 2012. PMID: 22902638
Estrogen signaling and epigenetic modifications, in particular DNA methylation, are involved in regulation of gene expression in breast cancers. Here we investigated a potential regulatory cross-talk between these two pathways by identifying their common target genes and e …
Estrogen signaling and epigenetic modifications, in particular DNA methylation, are involved in regulation of gene expression in breast …
Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study.
Gabriel B, Fischer DC, Orlowska-Volk M, zur Hausen A, Schüle R, Müller JM, Hasenburg A. Gabriel B, et al. J Soc Gynecol Investig. 2006 Jan;13(1):69-75. doi: 10.1016/j.jsgi.2005.10.001. J Soc Gynecol Investig. 2006. PMID: 16378916
OBJECTIVE: Although the Four and a Half LIM domain protein 2 (FHL2) has been suggested to play an important role in tumor development, this has not been investigated in breast cancer. ...CONCLUSION: The specific expression in tumor tissue points to an important func …
OBJECTIVE: Although the Four and a Half LIM domain protein 2 (FHL2) has been suggested to play an important role in tumor development …
17 results